DISCOVERY 1TO3

Overview

・DISCOVERY 1TO3 demonstrated rapid strut coverage of UltimasterTM DES, with the majority of strut coverage process taking place within the first month after stent implantation.
・The unique sequential OFDI analysis at 1, 2 and 3 months of treated lesions improves our insight into the embedding of novel metallic BP-DES.

Study Design

clinical_evidence_discovery_1to3_study_design

Study Outline

Patient background comparison with historical control

Baseline Patient Characteristicsn=60
Patients*
Age, y (mean±SD)67.2+9.9
Sex, males (%)73.3
Diabetes mellitus (%)23.3
Hypertension (%)63.3
Dyslipidemia (%)67.8
Family history of CAD (%)30.0
Current smoker (%)13.6
Previous PCI (%)26.7
Previous CABG (%)3.3
Previous MI (%)21.7
Angina status (%)
Stable patients56.7
ACS36.7
Moderate renal insufficiency GFR or MDRD=45-60), (%)20.0
Baseline lesion characteristics*
Vessels diseased2.2±0.5
Lesions detected3.2±1.6
Lesions treated-baseline1.4±0.6
Lesions treated-staged procedure at 1 mo (37 patients)1.1±0.4
Total lesions treated2.1±0.7
Stents implanted per lesion1.2±0.4
Implanted stent length per lesion, mm22.0±10.9
Implanted stent length per patient, mm50.4±21.4
ACS indicates acute coronary syndrome.
*One patient withdrew consent.

Result

Clinical outcomes

Frequency of strut coveredge of combind both single and overlapped stents at 1,2, and 3 months.

clinical_evidence_discovery_1to3_clinical_outcome

 

Reference